Nearly half of the nursing workforce reports symptoms of burnout, yet effective, system-level solutions remain limited. Jessica Rainbow, PhD, RN, CNE, and her interdisciplinary research team are leading a $3.6 million NIH-funded project to test a nurse-driven intervention designed to transform organizational conditions in hospital settings. By integrating nursing science, systems engineering, and clinical research, Rainbow’s work demonstrates how nurse-led, evidence-based innovation can strengthen work environments, improve patient outcomes, and support a more resilient health care workforce.